- Еуромедик, Булевар уметности 29, Београд
Invasive breast carcinomas - a pathologist's report
Др сци. мед. Зорка Миловановић
Прим. др Милош Почековац
INVASIVE CARCINOMA
Malignant cells stimulate the growth of the surrounding connective tissue – easier detection and palpation.
Ductal carcinoma (“No special type” – 75%),
E-Cadherin+ protein expression
Adenocarcinomas
Lobular carcinoma (10%), E-Cadherin-
Different histological types
Bilateral, multicentric – This type of cancer is difficult to detect on mammography – there is no marked tissue proliferation.
Other types of breast cancer
- Medullary carcinoma (2-10%), clearly circumscribed, T-lymphocyte infiltration.
- Mucinous (colloid) carcinoma (2%, elderly, rarely metastasizes).
- Tubular carcinoma (6%, associated with ductal carcinoma in situ-DCIS or lobular carcinoma in situ-LCIS.
Differential diagnosis of benign sclerosing lesions, excellent prognosis.
- Metaplastic carcinoma (1%, adeno ca, spindle, chondroid, bony, squamous differentiation.
- Metastatic tumors in the breast – lymphoma/leukemia, melanoma, from the lungs, stomach, ovaries.